Gonna need a source. We really have to stop with people just making claims regardless of what side their argument is on.
Testosterone deficiency is common in men with diabetes, regardless of the type. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention, whereas the utility of testosterone replacement remains to be established in prospective trials.
pubmed.ncbi.nlm.nih.gov
Diabetes and Low Testosterone
A link between
diabetes and low testosterone is well established. Men with diabetes are more likely to have low testosterone. And men with low testosterone are more likely to later develop diabetes. Testosterone helps the body's tissues take up more
blood sugar in response to
insulin. Men with low testosterone more often have
insulin resistance: they need to produce more
insulin to keep blood sugar normal.
Low testosterone is associated with other medical conditions, such as diabetes, obesity, heart disease, depression, and erectile dysfunction. Find out more from WebMD about the link and the questions that remain.
www.webmd.com
Non-alcoholic fatty liver disease (NAFLD) is a condition where there is excess accumulation of triglycerides in the liver in the absence of excess alcohol consumption. It ranges from simple steatosis to non-alcoholic steatohepatitis (NASH), which can ...
www.ncbi.nlm.nih.gov
Possible mechanisms underlying the association of low testosterone to NAFLD
Several different mechanisms could explain the observed association between low testosterone and NAFLD in males. For instance, low testosterone leads to accumulation of VAT, which can cause insulin resistance and increased exposure of the liver to free fatty acids. Moreover, low serum testosterone is associated with increased inflammation.[
51] Testosterone may also influence microRNAs in the liver or the activity of hepatic lipase as seen in male rats.[
52] Since testosterone can be converted to DHT and E2 by the enzymes 5α-reductase and aromatase respectively, DHT and E2 may play a part in linking low testosterone and NAFLD in men. The deficiency or inhibition of 5α-reductase triggers the development of hepatic steatosis in male mice,[
53;
54] suggesting low DHT levels may contribute to NAFLD. As DHT can initiate cell cycle arrest and apoptosis in androgen-sensitive liver cells by the PKR/eIF2a signaling cascade,[
55] low levels of DHT may increase HCC risk and possibly have a role in the pathogenesis of NAFLD. Further, low testosterone is associated with elevated E2 in men and this could be due to greater conversion of testosterone to E2. E2 has been found to reduce lipogenesis in male rats by decreasing fatty acid synthase and the phosphorylation of acetyl coenzyme A [
56], and thus, could affect testosterone's association with NAFLD.
And what do MTF hormone blockers do?