Calc War of the Worlds (1953) - Nuking the Martians

The army tries to nuke the Martians, which fails.
Also of importance is a line about the bomb;

War of the Worlds (1953) said:

This bomb is ten times more powerful than anything previously used. It's the latest thing in nuclear fission. Nothing like it has ever been exploded before.

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This would have included Ivy Mike of 1952, which had a yield of 10.4 megatons.

E = 10.4 X 10
= 104 megatons

Strong bomb and strong shields.

Final Results
Humanity nukes the Martians = 104 megatons