Fair vs thread. I'd assume they stop at those enemies that auto dodge and are fast af?
95% of Night City citizens have cyberware in some shape or form. Only ones that don't are Buddhist monks. Who deem cyberware blasphemous. And one Ripperdoc in Watson because he finds them distracting when doing surgery on people. The crazy fast people in Night City all have Reflex Tuners, Synaptic Accelerators, Kerenzikovs, or Sandevistans. At point blank those enemy types can even dodge shots from Tech Weapons. Which in this context are electromagnetic railguns. Tech Weapons themselves can fire slugs at such speeds that they're Anti-Tank weapons in the context of Cyberpunk 2077. Where tanks can survive nukes. So, they would be
ridiculously fast. Then there's Maneuvering Systems that enhance a person's nervous system to the point where they can jump off the air, and move so quickly that they can push themselves away from it to dodge in mid-air. Not sure how quantifiable it is, but it's pretty ridiculous. They're moving so fast that they can hit the air like it's a wall.
Even T-Bug has millisecond reflexes, casually analyzing data in that time-frame, and she is a Netrunner who
avoids combat. Preferring to deal with people at a distance via hacking.
Besides that, there's a lot of cyberware that can defend people from attacks against their brain or body. Such as Self-Ice. Which automatically stops any hacking attempts. Which isn't hard to get, and things like Pain Editors which even Fingers has access to. And he is a back alley Ripperdoc. Who is located in a junkie crack den. Which basically shuts off any sensation of pain. Which would be super effective against some of The Volturi, and other psychic vampires.
Subdermal Armor is also commonplace, and RealSkin is available to just about anyone. The Moxes for example extensively use the latter, and various reflex boosters. RealSkin is that plastic you see people use to replace their epidermis, and by default it's bullet-proof against Power Weapons. In the context of Cyberpunk 2077. Where even Power Weapons hit as hard as explosives. They also use Sandevistans, and Mantis Blades.
Monowire is available to a lot of people, and it is able to cut through things down to a molecular/atomic level. However, various Katanas and Mantis Blades are as effective as it is.
Dated reflex boosters from 2020 make normal human beings ten times faster than peak human. The modern ones in 2077 blow them out of the water by a whole magnitude, and Subdermal Armor back then was still able to let Adam Smasher and Morgan Blackhand survive the nuke in Arasaka Tower.