2nd Awakening characters are where they reach universe level and can fight Time Lords that can summon big bangs. Creator can summon them and tap into the power of the big bang or a supernova with his temporal time rifts. Creator can even rapture time, move spaces, or meld them together. They fought a being named The Gate (Black/White Universe) [Cosmo Fiend: Rosen], who can summon planets and change the color of the terrain in outer space. He can even use the force of the planets in his universe to absorb other planets.
In DNF Duel, Striker's Ultimate looks like she is channelling her Nen to punch with a galaxy.
The Final Boss in DNF Duel is the Lost Warrior. He's Carloso's Fragment, who is basically DFO's god. Carloso is the literal creator of DFO's Multiverse, the Knight Class in Dungeon Fighter Online is literally tasked with finding him and his fragments and there is one for each Universe. When Carloso reabsorbs just one fragment, it causes a virtual universal timeline shift. This is called Metastasis.
wiki.dfo.world
Lost Warrior: "He's... coming..."
If player is a Knight: <player>: "Ah!"
Lost Warrior: "I'm lost. I don't know where I'm going, where I came from, or even who I am. Yes, everything has disappeared--no, they never existed. They're present, but they are not actually existing. Therefore everything is meaningless. Everything except for the fact that he's coming."
If player is a Knight: <Player>: "(This man...He's Carloso's Fragment! Which time slot are we in? I wasn't the only knight looking for Carloso's Fragments. There really has been someone else who's looking for Carloso...)"
If player is a Knight: Siran: "You're back. What do you think of him?"
<Player>: (I can't tell him about Carloso. Mm, then what should I tell him instead?) "Something really is off about him, but I couldn't figure it out. I didn't even know which point of time in the past we were in. But I don't think you should worry about him."
Siran: "Hm, I was sure something was off about him... Oh well, you think I shouldn't worry, so I won't. Thanks."
The Metastasis completely and utterly fucks up the world in such a fashion that before a retcon or a change, it completely changed and shifted the timeline into an entirely different timeline entirely. Then, after the retcon, we find out the original timeline isn't gone after all, and thus you can say instead, it created an entirely new timeline and reset it completely.
I'm not sure where Neo: Awakening are, but they're stronger than their 2nd Awakening. So probably universal+ or at least universal.