Famitsu: The final boss of the collab was Only One/Number One - Shiny Star, but that one was only at a 2-star level. Could Chaldea win a head-on confrontation with it if it was at 5-stars?
Nasu: Since the event would be confirmed already, it would depend on the Servants involved. Maybe someone on Divine Spirit-level could do it. If it were the Kali/Durga from OC1, I imagine it would go something like "Silence, and vanish alongside the world" as half the world blows up, but that would still be preferable to the whole world being caught up in it, right?
Remember, at that point the protagonist and Aoko would be out of luck in terms of matching it with combat ability. At the stage when Aoko was dispatched, lots of factors were involved, but they were still ultimately manageable.