I want to just point this out from another user trying to defend a user calling out people trying to point out how stupid it is to apply physics on one end but not the other:
Depends of the physics being broken.
No... no it doesn't. That's precisely the issue that you have people retorting is absolutely stupid. There is no "depends", it's either okay physics are being broken or fiction itself should be ignored because it's not based on physics.
Tighten picking up the building and the ball not disintegrating at the speeds thrown canbe dismissed as an artistic interpritation of physics because the intent behind the scene is that Tighten is strong enough to toss a skyscraper, and that mark can throw a ball hard enough that it orbits the earth.
Getting a speed from that scene is a lot harder as we don't get a timeframe for it, but the atmospheric effects suggest the ball wasn't going nearly that fast.
...Again, if we are applying physics evenly, any building Tighten would pick up would immediately break due to it's weight unless he has tactile kinesis which isn't real either. Hell, Tighten trying to pick up heavy shit would cause HIM to sink into the Earth well before lifting it up.
We cannot pretend that should only be the case for Omniman or Mark playing catch by throwing the Baseball around the Planet.
Re-entry speed we're things leave fire trails is ~8km/s. The ball lands in Nolans hand and is only red hot at one spot so it can't have been going that fast. Thats also around the minimum speed the ball would need to orbit the earth at near ground level.
So 8km/s is a good estimate of how fast the ball was going.
The show Invincible does have scenes were people moveing orbit the earth in seconds speeds (5000km/s) and it demonstrates all the associated collateral effects (Nolan detroying that civilisation). So the writers are clearly aware of what something moving that fast would do.
Yeah, that's not how that works at all...
Yes, we do need to go by time and/or other ideals to get a true grip on how fast that ball is going but here's also the problem with that:
Time in comics is flexible. Each panel shows a single event, which is usually accompanied by a length of dialog, which must take some time to say. This disparity is usually accepted if it isn't taken to extremes. But often, characters will …
tvtropes.org
This is ALSO a thing in fiction and it further muddies the waters of Omni-Man and Mark's game of catch. How fast is the ball going versus the conversation Mark and him have? Because it's clearly done for the sake of convenience as when we get Mark throwing it, the ball very much moves faster than their conversation by Omni-Man throwing it despite the show heavily implying that it's going at the same speed Mark threw it(With him reciting difficulty hearing it and seeing it coming)
Its unlikely the intent of th scene was that Mark was throwing the ball as fast as Omniman destroying a civilisation.
However it also means that Mark thowing the ball at 5000km/s is in the 'reasonable calcs' realm of estimates.
Yeah, that's how it's supposed to work...
We primarily apply these feats and scale them too in order for them to properly work. So by the very point you put up, this is a worthless argument because there is no "There's a difference between physics" because there is only just one:
Whether you go with all of it or none of it because fiction never scales with reality in any fashion, not even in Soft Sci-Fi settings.
EDIT: I feel like people seriously misunderstand the point of fiction bending the laws of physics around does not mean the absence of physics or them completely ignoring it. The ability to ignore the laws of Inertia does not mean that you suddenly have infinite speed but it does mean you can ignore the issues humans have with being able to maintain their velocity while moving left and right. The ability to grab a Building, a Planet or otherwise without crashing through it usually means you have some level of tactile kinesis, not the fact that physics have gone to take a break.
Hell, we see it all the time with people being able to use Fire or Ice abilities but not only not instantly killing themselves for basically really crap temperatures but also not being able to use them TOGETHER because all they are is either you making Molecules vibrate really fucking fast... or making them dead still. It works both ways because that's how fiction works.