These two fought to a stalemate in Resident Evil 6, so by all accounts they're meant to be equals in-verse and certainly treated that way. Leon's agility is as fucking absurd as Chris' strength is, so it's tough to call a winner in a fight here.
1:00 is the aforementioned fight between the two.
Nice showing of how ridiculously agile and durable Leon is, bearing in mind this dude had already beaten Chris by this point.
Not saying Chris ISN'T agile as he showcases some good bullet timing here, he's just not as agile as Leon is.
See what I mean?
It's really tough to call an outright winner in a fight but I'd almost lean towards Leon.
The only thing either's done that I couldn't see the other replicating is defeating Wesker, because it's specifically the history Chris has with Wesker that causes him to toy with Chris and leave the latter (plus Sheva let's not forget) capable of eventually killing him. I can't see Leon pulling it off on his own.