Goku and Buu fight nearly destroy Kaioshin Realm which size is confirmed around 1/10 macrocosm.
Here the scene of Goku order Kaioshin and the others to leave Kaioshin Realm.
In Episode 279, before the fight even began, Goku tells the Kais and Dende to leave to one of the planets in the Lower Realm, with the Elder Kai even treating the destruction of the Kaioshin Realm as a possibility. This was further reinforced throughout the SSJ3 Goku
vs. Kid Buu fight in Episode 280, with Kibito Kai stating they were destroying the Kaioshin Realm. Kid Buu also
caused extensive damage to the Sacred World of the Kais in the former episode, which could argued to be the size of many galaxies.
Episode 287 Elder Kai also commented the fight between Kaioshin Realm is destroyed.
Buuhan almost destroy Universe if Vegito don't stop him.
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Daizenshuu also note the tecnique about Buuhan destroy universe is the same power which made him out of Hyperbolic Time Chamber.
Databook also claim Majin Buu is monster who can destroy Universe.
Enfrentamiento con los subordinados de Babidi
Para evitar que Bu, un monstruo con el poder de destruir el universo, vuelva a la vida. Kalo Shin y el grupo de Goku Imumpen en la guarida de Babidi. Sin embargo, Dabra, el rey del mundo de los demonios, convertido en subordinado de Babidi, petrifica a Krilin y a Piccolo. Para salvarlos, y aun sabiendo que es un trampa, Goku y el resto de los luchadores entran en la nave de Babidi, donde deberán enfrentarse a todos sus esbirros. Tras derrotarlos con facilidad. llegan ante Babidi, que afirma que Dabra los vencerà a todos.
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Confrontation with Babidi's subordinates
To prevent Buu, a monster with the power to destroy the universe, from coming back to life. Kalo Shin and Goku's group Imumpen in Babidi's lair. However, Dabra, the king of the demon world, who has become Babidi's subordinate, petrifies Krillin and Piccolo. To save them, and even knowing that he is a trap, Goku and the rest of the fighters enter Babidi's ship, where they must face all of his minions. After defeating them with ease. They arrive before Babidi, who claims that Dabra will defeat them all.
There also statement Goku need Super Genki-Dama with energy from entire universe to destroy Majin Buu in DBZ episode 288.