That was unique to Soldier Boy. The blast he made use of was extremely radioactive, and burned through any Compound V. Rendering anyone with powers powerless. How he was immune to it was a mystery, and might have something to do with the experiments backfiring. Instead of killing Soldier Boy, they made him stronger.He is Soldier Boy's son, who was tortured for decades by the Russians and they tried to harm/kill with radiation, poison and so.
If Homelander inherited some of his father inmunities then he will be fine agaisnt most of the conventional toxins in the world , like the only gas that can K.O Soldier Boy was Novichok , the most dangerous chemical weapon ever made IRL.
Which puts into question whether Homelander can actually survive large doses of radiation. When it has been shown to fry V.