I dont think theres a single power system ive seen so far that can't just murder or horribly disfigure you in some way. its wild
I dont even think Ki or Chakra is safe
Not even the Nasuverse is safe with it as it's power systems are... a mixed bag.
You are either born into a decent Magus Family... or you end up like Waver... or you are just born an insane mutant and that Mage Society finds out about your existence and takes you in.
Of course, you can end up in a variety of Bad Ends but none of that is due to the powers not fucking you over but more of jealousy and stepping on the wrong fucker's toes.
You can just be a superhuman motherfucker but that requires basically training for years and breaking your body apart by being part of the Church to the point even Mages fear you... or you are born deep in the Mountains/away from Society which turns you into a truly broken son of a bitch because if you don't know what limits Humans have, why would it affect you? Until you DO end up in Human Society and you lose your beyond human tier strength because you then realize where Humans are limited at.
Let's not get into Servant details where the older the legend, the more powerful they are... or if you are like Tesla, you revolutionized Humanity so hard, you get a jump start... or be like Edmond Dantes and find some absolute bullshit Magical Circuits in your treasure that stays with you even in death where it was just one time use while alive.
Otherwise, you end up pretty weak and can get murdered by say Heracles in a fight
Hope you get a bullshit Noble Phantasm that makes you OP atleast in one area or you are practically just eh.